In My Girlfriend's Amnesia, the way you make up your mind is what dictates how the game gets played. You are facing a situation where your girlfriend has brain damage from a car accident. She has recurring amnesia, which means she forgot the past 2 years, and every day she forgets what happened the day before and you have to start all over again with her. Therefore, you have to show her you are her boyfriend over and over. Plus, the accident is being investigated by the cops too. Your girlfriend’s twin sister comes into the picture too, so that complicates things. There are three choices: neutral, gentleman or jerk, and each brings different results.