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In Kathoey, May Kha has always helped Mi Kha cover up her pain from her superstitious conservative father with the help of makeup. Mi is a girl trapped in a male's body, and her sister May has always helped her live through the pain. Mi wants to move to the USA with her sister for a year to get sex reassignment surgery. May is happily married in America and struggles to keep up with her busy life as a doctor. Mi wants to become a woman and be a world-famous actress. Will both of these two make their dreams come true in America?